Fresh analysis indicates that people who stop using blockbuster GLP-1 drugs like semaglutide or tirzepatide tend to recover reduced body mass far faster than those who stop conventional diet and exercise programs.
Findings released in a major medical journal demonstrates that while overweight individuals frequently drop a large proportion of their total mass while on the medication, the weight returns at an average rate of nearly a kilo each month upon discontinuation.
"Users using these treatments must be informed of the potential of fast rebound weight gain when the therapy concludes," warns lead investigator Dr. Susan Jebb.
This pace of regain means a reversion to pre-treatment weight within about a year and a half.
Weighing Approaches
The analysis, which reviewed dozens of studies involving over 9,000 of patients, contrasted the results of the injectable medications with older methods.
Scientists note that individuals who lose weight through diet and exercise usually have a slower weight regain—approximately 100 grams monthly—after stopping.
Understanding the Fast Regain
Doctors propose the mechanism of the injections accounts for the accelerated rebound.
These medications mimic a natural hormone called GLP-1, which helps regulate feelings of fullness.
"Long-term administration of the hormone levels several times higher than the body's typical production might result in the body to generate a reduced amount of its endogenous hormone, and may also diminish responsiveness to its actions," said Dr. Adam Collins, a nutrition expert.
"Withdrawal of this medication leads to hunger is no longer kept in check, making excessive eating a significant risk."
A Chronic Condition?
The NHS suggest the jabs for individuals with weight-linked health risks, alongside prescribed diet and exercise modifications.
Professionals argue that, considering the high risk of weight regain, the therapy might need to be life-long.
This opinion is echoed by pharmaceutical companies, who note that the results "emphasize the persistent nature of obesity," akin to managing conditions like high blood pressure.
Patient Testimonies
People who have stopped the medication report a sudden return of cravings.
"It was like a trigger flipping and you're instantly starving," described an individual.
The struggle is exacerbated if individuals have not adopted permanent lifestyle or habit modifications during treatment.
Growing Interest
Survey data suggest that millions of people in the UK have tried weight-loss jabs in the last 12 months, with demand remaining high.
- Use is greater among women compared to men.
- The 40s and 50s demographic shows the greatest usage rates.
- Many access the medications through private prescriptions rather than public health services.
Ultimately, researchers emphasize that while the jabs are potent tools for shedding pounds, they are not a magic solution and lasting health benefits hinges on integrated behavioural management.
